Zolvo
Generic: Voriconazole
Daily Dose:
Duration:
Alternatives (24)Cheaper & Alternative Brands (200 mg)
Same active generic (Voriconazole), same form (Tablet), exact same strength (200 mg)
Clinical Prescribing Information
Medical monograph and safety information for healthcare professionals & patients.Indications & Clinical Uses
Azofend is an azole antifungal medicine. It is indicated for use in patients 12 years of age and older in the treatment of following fungal infections-
Invasive aspergillosis
Candidemia (nonneutropenic) and disseminated candidiasis in skin, abdomen, kidney, bladder wall and wounds
Esophageal candidiasis
Serious infections caused by Scedosporium apiospermum and Fusarium Species including Fusarium solani
Patients intolerant of, or refractory to other therapy.
Dosage & Administration
Oral-
Voriconazole tablet and powder for suspension are to be taken at least one hour before or one hour following a meal:
At or over 40 kg body weight
: Loading dose regimen is 400 mg or 10 ml every 12 hours (for the first 24 hours) and maintenance dose (after first 24 hours) is 200 mg or 5 ml twice daily.
Below 40 Kg body weight
: Loading dose regimen is 200 mg or 5 ml every 12 hours (for the first 24 hours) and maintenance dose (after first 24 hours) is 100 mg or 2.5 ml twice daily. Or, as directed by the registered physician.
Injection-
Invasive Aspergillosisd:
Loading dose
: 6 mg/kg 12 hourly for the first 24 hours.
Maintenance Dose
: 4 mg/kg 12 hourly.
Candidemia in nonneutropenic patients and other deep tissue Candida infections:
Loading dose
: 6 mg/kg 12 hourly for the first 24 hours.
Maintenance Dose
: 3-4 mg/kg 12 hourly.
Scedosporiosis and Fusariosis:
Loading dose
: 6 mg/kg 12 hourly for the first 24 hours.
Maintenance Dose
: 4 mg/kg 12 hourly.
Contraindications
Known hypersensitivity to Voriconazole or any other components of this drug-
Co-administration with terfenadine, astemizole, cisapride, pimozide or quinidine, sirolimus due to risk of serious adverse reactions
Co-administration with rifampin, carbamazepine, long-acting barbiturates, efavirenz, ritonavir, rifabutin, ergot alkaloids and St. John's Wort due to risk of loss of efficacy
Side Effects & Adverse Reactions
The most common side effects are abdominal pain, anemia, blurred vision, headache, chest pain, nausea and diarrhea.
Warnings & Precautions
Long term exposure (treatment or prophylaxis) greater than 180 days requires careful assessment of the benefit-risk balance. Squamous cell carcinoma of the skin (SCC) has been reported in relation with long-term Azofend treatment.
Pharmacology & Mechanism of Action
Voriconazole is a triazole antifungal medication used to treat serious fungal infections. Voriconazole binds and inhibits ergosterol synthesis by inhibiting CYP450-dependent 14-alpha sterol demethylase. The inhibition of 14-alpha sterol demethylase results in a depletion of ergosterol in fungal cell membrane.