Umactin
Generic: Nitrofurantoin
Daily Dose:
Duration:
Cheaper & Alternative Brands (100 mg)
Same active generic (Nitrofurantoin), same form (Capsule), exact same strength (100 mg)No other brands are currently registered in Bangladesh for the 100 mg presentation. Below are available brands for Nitrofurantoin in other strengths:
Clinical Prescribing Information
Medical monograph and safety information for healthcare professionals & patients.Indications & Clinical Uses
Euronit is specifically indicated for the treatment & prophylaxis of urinary tract infections caused by susceptible strains of Escherichia coli, Enterococci, Staphylococcus aureus, Staphylococcus saprophyticus and certain susceptible strains of Klebsiella and Enterobacter species.
Dosage & Administration
Nitrofurantoin tablet (In adults):
Uncomplicated urinary tract infections
: 50-100 mg four times a day- the lower dosage level is recommended. Therapy should be continued for one week or for at least 3 days after sterility of the urine is obtained.
For long-term suppressive therapy
: In adults, a reduction of dosage to 50-100 mg at bedtime may be adequate.
Nitrofurantoin capsule (In adults):
Acute Uncomplicated Urinary Tract Infections (UTIs)
: 50 mg four times daily for 7 days.
Long term suppression
: 50-100 mg once a day.
Prophylaxis
: 50 mg four times daily for the duration of procedure and for three days thereafter.
Nitrofurantoin SR capsule:
Adults and Children over 12 years
: One 100 mg capsule every 12 hours for seven days.
Genito-urinary surgical prophylaxis
: One capsule twice daily on day of procedure and for next 3 days.
Nitrofurantoin suspension: Children: 5-7 mg/kg/day in four divided doses (contraindicated under one month of age). The average dose of Nintoin suspension for pediatric patients are as follows-
7 to 11 kg: ½ (2.5 ml) teaspoonfuls 4 times daily.
12 to 21 kg: 1 (5 ml) teaspoonfuls 4 times daily.
22 to 30 kg: 1½ (7.5 ml) teaspoonfuls 4 times daily.
31 to 41 kg: 2 (10 ml) teaspoonfuls 4 times daily.
Therapy should be continued for one week or for at least 3 days after sterility of the urine is obtained. For long-term suppressive therapy in children, doses as low as 1 mg/kg per 24 hours, given in a single dose or in two divided doses, may be adequate.
Contraindications
Anuria, oliguria or significant impairment of renal function are contraindications. This drug is contraindicated in pregnant patients at 38-42 weeks, during labor and delivery. Nitrofurantoin is also contraindicated in those patients with known hypersensitivity to Nitrofurantoin.
Side Effects & Adverse Reactions
The most frequent clinical adverse events are nausea, headache, and flatulence. Other less occurred adverse events are diarrhea, dyspepsia, abdominal pain, constipation, emesis, dizziness and drowsiness.
Warnings & Precautions
If acute, sub-acute or chronic pulmonary reactions occur, Euronit should be discontinued. Antacid preparations containing magnesium trisilicate should not be taken while taking Euronit.
Pharmacology & Mechanism of Action
Nitrofurantoin is an antibacterial agent specific for urinary tract infections. Nitrofurantoin is highly soluble in urine, to which it may impart a brown color. Nitrofurantoin inactivates or alters bacterial ribosomal proteins and other macromolecules. Nitrofurantoin has been shown to be active against the following bacteria: Gram-Positive Aerobes Staphylococcus saprophyticus, Coagulase-negative staphylococci (including Staphylococcus epidermidis), Enterococcus faecalis, Staphylococcus aureus, Streptococcus agalactiae, Group D streptococci, Viridans group streptococci. Gram-Negative Aerobes- Escherichia coli, Citrobacter amalonaticus, Citrobacter diversus, Citrobacter freundii, Klebsiella oxytoca, Klebsiella ozaenae.