Thenxet
Generic: Flupentixol + Melitracen
Daily Dose:
Duration:
Alternatives (24)Cheaper & Alternative Brands (0.5 mg+10 mg)
Same active generic (Flupentixol + Melitracen), same form (Tablet), exact same strength (0.5 mg+10 mg)
Clinical Prescribing Information
Medical monograph and safety information for healthcare professionals & patients.Indications & Clinical Uses
Flupentixol and Melitracen tablet is indicated in-
Anxiety
Depression
Apathy
Psychogenic depression.
Depressive neurosses.
Masked depression.
Psychosomatic affections accompanied by anxiety and apathy.
Menopausal depressions.
Dysphoria and depression in alcoholics and drug addicts.
Dosage & Administration
Adults
: Usually 2 tablets orally daily in the morning and noon. In severe cases, the morning dose may be increased to 2 tablets.
Elderly patients
: 1 tablet in the morning.
Maintenance dose
: Usually 1 tablet orally in the morning. In cases of insomnia or severe restlessness, additional treatment with a sedative in the acute phase is recommended.
Contraindications
The immediate recovery phase after myocardial infarction.
Defects in bundle-branch conduction.
Untreated narrow-angle glaucoma.
Acute alcohol, barbiturate and opiate intoxications.
This tablet should not be given to patients who have received an MAO-inhibitor within two weeks.
Not recommended for excitable or overactive patients since its activating effect may lead to exaggeration of these characteristics.
Side Effects & Adverse Reactions
In the recommended doses side effects are rare. These could be transient restlessness and insomnia.
Warnings & Precautions
If previously the patient has been treated with tranquillizers with sedative effect these should be withdrawn gradually.
Pharmacology & Mechanism of Action
This consists of two well known and well proven compounds: flupentixol-a neuroleptic with anxiolytic and antidepressant properties of its own when given in small doses, and melitracen-a bipolar thymoleptic with activating properties in low doses. In combination the compounds render a preparation with antidepressant, anxiolytic and activating properties. Maximal serum concentration is reached in about 4 hours after oral administration of flupentixol and in about 4 hours after oral administration of melitracen. The biological half-life of flupentixol is about 35 hours and that of melitracen is about 19 hours. The combination of flupentixol and melitracen does not seem to influence the pharmacokinetic properties of the individual compounds.