Proston
Generic: Dinoprostone
Application:
Course Duration:
Cheaper & Alternative Brands (0.5 mg/3 gm)
Same active generic (Dinoprostone), same form (Vaginal Gel), exact same strength (0.5 mg/3 gm)No other brands currently registered with this exact active generic and dosage form.
Clinical Prescribing Information
Medical monograph and safety information for healthcare professionals & patients.Indications & Clinical Uses
Proston is indicated to helps in the induction of labor, and widens the cervix for easy delivery. It is also used to initiate an abortion at about 12 to 20 weeks of pregnancy and also indicated to help clean out the vagina after a miscarriage.
Dosage & Administration
For adult patients
: The recommended dose of Dinoprostone gel is 0.5 mg. After placement of the gel, the patient should be instructed to remain in the dorsal position for 10-15 minutes to minimize gel leakage.
Geriatrics (>65 years of age)
: Dinoprostone gel has not been studied in this patient population and is not recommended for use.
Pediatrics (<18 years of age)
: Dinoprostone gel has not been studied in this patient population and is not recommended for use.
Contraindications
Dinoprostone Gel is contraindicated in the following patients: Hypersensitivity to this drug or to any ingredient in the formulation, Patients in whom oxytocic drugs are contraindicated or where prolonged contractions of the uterus are considered inappropriate, history of cesarean section or major uterine surgery, major degree of cephalopelvic disproportion, history of difficult labor and/or traumatic delivery, Grand multiparae with six or more previous term pregnancies, suspected or clinically evident pre-existing fetal distress, Patients with overdistention of the uterus (multiple pregnancy, polyhydromnias), ruptured amniotic membranes or suspected chorioamnionitis, Patients with unexplained vaginal bleeding during the pregnancy, fetal malpresentation, gynecological, obstetrical or medical conditions that preclude vaginal delivery, history of epilepsy, patients whose pregnancy is complicated by an abnormal position of the placenta or umbilical cord.
Side Effects & Adverse Reactions
Common
: Abnormal Labor Affecting Fetus, Fetal Heart Rate Disorder, Fetal Distress Syndrome, Uterine Hypertonus.
Uncommon
: Nausea, Vomiting, Fever, Abdominal Pain, Diarrhea.
Rare
: Disseminated Intravascular Coagulation, Uterine Rupture, Anaphylactic Reaction.
Warnings & Precautions
Caution should be exercised in administration of Proston Gel in patients with: Hypertonus, Sustained Uterine Contractility or Fetal Distress, Hypertonic Uterine Contractility or Tetanic Uterine Contractions, Asthma, Glaucoma, Heart Diseases, Depression.
Pharmacology & Mechanism of Action
Dinoprostone is a naturally-occurring biomolecule. It functions as a local hormone. Dinoprostone causes the cervix muscles to dilate and become relaxed. This eventually encourages the muscle of uterus to contract during labour. Its functions are similar to that of PG E-2 or Prostaglandin E2.