PEG-Epo
Generic: Pegylated Erythropoietin
Daily Dose:
Course Duration:
Cheaper & Alternative Brands (50 mcg/0.3 ml)
Same active generic (Pegylated Erythropoietin), same form (IV/SC Injection), exact same strength (50 mcg/0.3 ml)No other brands are currently registered in Bangladesh for the 50 mcg/0.3 ml presentation. Below are available brands for Pegylated Erythropoietin in other strengths:
Clinical Prescribing Information
Medical monograph and safety information for healthcare professionals & patients.Indications & Clinical Uses
PEG-Epo is indicated for the treatment of anemia associated with chronic kidney disease (CKD) in adult patients on dialysis and patients, not on dialysis.
It is not indicated for use:
In the treatment of anemia due to cancer chemotherapy.
As a substitute for RBC transfusions in patients who require immediate correction of anemia.
Dosage & Administration
Initiate Pegylated Erythropoietin treatment when the hemoglobin level is less than 10 g/dL. If the hemoglobin level approaches or exceeds 11 g/dL, reduce or interrupt the dose of Pegylated Erythropoietin.
If the hemoglobin rises rapidly (e.g, more than 1 g/dL in any 2 week period), reduce the dose of Pegylated Erythropoietin by 25% or more as needed to reduce rapid responses. And for patients who do not respond adequately, if the hemoglobin has not increased by more than 1 g /dL after 4 weeks of therapy, increase the dose by 25%
For patients who do not respond adequately over a 12 week escalation period, increasing the Pegylated Erythropoietin dose further is unlikely to improve response and may increase risks
For patients with CKD on dialysis:
The recommended starting dose of Pegylated Erythropoietin for the treatment of anemia in adult CKD patients who are not currently treated with an ESA is 0.6 mcg/kg body weight administered as a single IV or SC injection once every two weeks.
Once the hemoglobin has been stabilized, it may be administered once monthly using a dose that is twice that of the every two-week dose and subsequently titrated as necessary.
For patients with CKD not on dialysis:
The recommended starting dose of Pegylated erythropoietin for the treatment of anemia in adult CKD patients who are not currently treated with an ESA is 0.6 mcg/kg body weight administered as a single IV or SC injection once every two weeks.
Once the hemoglobin has been stabilized, it may be administered once monthly using a dose that is twice that of the every two-week dose and subsequently titrated as necessary.
Conversion from another ESA to Pegylated erythropoietin: It can be administered once every two weeks or once monthly to patients whose hemoglobin has been stabilized by treatment with an ESA.
Side Effects & Adverse Reactions
Increased Mortality, Myocardial Infarction, Stroke, and Thromboembolism
Increased mortality and/or tumor progression in patients with cancer
Hypertension
Seizures
Pure red cell aplasia
Serious allergic reactions
Warnings & Precautions
Using ESA to target a hemoglobin level of >11 g/dL increase the rate of serious adverse cardiovascular reactions. It should be used with caution in patients with co-existant cardiovascular disease, stroke, seizure etc.
Control hypertension prior to initiating of and during treatment with it
Monitoring of patients for the change in seizure frequency or premonitory symptoms.
If severe anemia and low reticulocyte count develop during the treatment, withhold it and evaluate patients for neutralizing antibodies to erythropoietin
Pharmacology & Mechanism of Action
Pegylated erythropoietin is an erythropoietin receptor activator with greater activity in vivo as well as increased half-life, in contrast to erythropoietin. It differs from erythropoietin through the integration of an amide bond between the N-terminal amino group or the ε-amino group of any lysine present in erythropoietin, predominantly Lys52 and Lys45 and Pegylated Erythropoietin (PEG).