Parixol
Generic: Pramipexole
Daily Dose:
Duration:
Cheaper & Alternative Brands (180 mcg)
Same active generic (Pramipexole), same form (Tablet), exact same strength (180 mcg)No other brands are currently registered in Bangladesh for the 180 mcg presentation. Below are available brands for Pramipexole in other strengths:
Clinical Prescribing Information
Medical monograph and safety information for healthcare professionals & patients.Indications & Clinical Uses
Parixol tablet is indicated for the treatment of-
Parkinson's disease used alone or as an adjunct to levodopa with dopa-decarboxylase inhibitor
Moderate to severe restless legs syndrome
Dosage & Administration
The recommended dose of Pramipexole is as follows-
Parkinson's disease:
Initial dose
: 88 micrograms 3 times daily, dose doubled every 5-7 days if tolerated to 350 micrograms 3 times daily; further increased if necessary by 180 micrograms 3 times daily at weekly intervals
Maximum dose
: 3.3 mg daily in 3 divided doses. During pramipexole dose titration and maintenance Levodopa dose should be reduced.
Restless legs syndrome:
Initial dose
: 88 micrograms once daily 2-3 hours before bedtime, dose doubled every 4-7 days if necessary to 350 micrograms daily.
Maximum dose
: 540 micrograms daily.
Use in children: Pramipexole is not recommended for children below 18 years of age.
Contraindications
Pramipexole is contraindicated in patients with known Hypersensitivity to the active substance or to any of the excipients.
Side Effects & Adverse Reactions
The common side effects are dizziness, dyskinesia, nausea, hypotension, abnormal dreams, confusion, constipation, delusion, hallucinations, headache, hyperkinesia, increased eating (binge eating, hyperphagia), insomnia, libido disorders, nausea, peripheral oedema, paranoia, pathological gambling, hypersexuality and other abnormal behaviour, somnolence, weight increase, sudden onset of sleep, pruritus and rash and other hypersensitivity.
Warnings & Precautions
Caution should be taken in patients with psychotic disorder, ophthalmologic monitoring is recommended at regular intervals, severe cardiovascular disease and renal impairment.
Pharmacology & Mechanism of Action
The exact mechanism of action of pramipexole as a treatment for Parkinson's disease is unknown at this time. It is thought, however, that the ability of pramipexole to cause stimulation of the dopamine receptors in the striatum of the brain, a region that receives a vast array of neurological input and is responsible for a wide variety of functions, may be involved. Studies performed in animals show that pramipexole influences striatal neuronal transmission rates following activation of dopamine receptors. Pramipexole is considered a non-ergot dopamine agonist that shows specificity and strong activity at the D2 subfamily of dopamine receptors in vitro, binding selectively and dopamine D2 receptors and showing a preference for the dopamine D3 receptor subtype rather than other subtypes. The clinical significance of this binding specificity is unknown.