Nikethamide
Generic: Nikethamide
Daily Dose:
Course Duration:
Cheaper & Alternative Brands (250 mg/ml)
Same active generic (Nikethamide), same form (Injection), exact same strength (250 mg/ml)No other brands currently registered with this exact active generic and dosage form.
Clinical Prescribing Information
Medical monograph and safety information for healthcare professionals & patients.Indications & Clinical Uses
Nikethamide is indicated in-
Acute respiratory failure
Respiratory depression following anesthesia
CNS depression
Dosage & Administration
2 to 10 mL by slow IV injection of the usual 25% solution every 20 to 30 minutes if necessary. Infants and children are particularly susceptible to toxic effects of nikethamide.
Contraindications
Porphyria, epilepsy or other convulsive disorders, perebral oedema, airways obstruction, cerebrovascular accident, severe hypertension & ischemic heart diseases.
Side Effects & Adverse Reactions
Dyspnoea, respiratory problems such as coughing bronchospasm. Other CNS side effects include convulsion, headache & dizziness. Cardiovascular side effects inlude Iteration of blood pressure & cardiac arrhythmia. Over dosage may cause nausea, vomiting & diarrhoea.
Warnings & Precautions
It should not used in less severe degrees of hypertension or impaired cardiac reverse & hepatic dysfunction.
Pharmacology & Mechanism of Action
Nikethamide also known as nicotinic acid diethylamide is a central & respiratory stimulant. It has direct stimulatory action on CNS, increases the frequency & depth of breathing. It has no immediate impact on the cardiovascular system. It is extensively metabolized in liver. All metabolites & a small amount of unchanged drug is excreted in urine.