Neforex
Generic: Nefopam Hydrochloride
Daily Dose:
Duration:
Alternatives (1)Cheaper & Alternative Brands (30 mg)
Same active generic (Nefopam Hydrochloride), same form (Tablet), exact same strength (30 mg)
Clinical Prescribing Information
Medical monograph and safety information for healthcare professionals & patients.Indications & Clinical Uses
Efopam is indicated for the relief of acute pain, including post-operative, dental, musculo-skeletal and acute traumatic pain. It is also indicated in chronic pain like cancer pain.
Dosage & Administration
Tablet-
Adults
: Dosage may range from 30 to 90 mg three times daily depending on response. The recommended starting dosage is 2 tablets three times daily.
Elderly
: Elderly patients may require reduced dosage due to slower metabolism. It is strongly recommended that the starting dose does not exceed 1 tablet 3 times daily.
Injection-
Adult
: 20 mg by IM injection, repeated every 6 hours if necessary. It also be given by slow IV injection in similar dose.
Children: Not recommended for children under the age of 12 years.
Contraindications
Nefopam Hydrochloride is contraindicated in patients with a history of convulsive disorders and should not be given to patients taking monoamine oxidase (MAO) inhibitors. It is also should not be used in the treatment of myocardial infarction.
Side Effects & Adverse Reactions
Efopam is generally well tolerated. However the most common side-effects are nausea, nervousness, dry mouth, lightheadedness and urinary retention. The less common side-effects are vomiting, blurred vision, drowsiness, sweating, insomnia, headache, confusion, hallucinations, tachycardia and aggravation of angina.
Warnings & Precautions
Efopam should be used with caution in patients with glaucoma and with or at risk of urinary retention. Caution should be exercised when Efopam is administered concurrently with tricyclic antidepressants. Caution should also be exercised in patients with a history of ischaemic heart disease.
Pharmacology & Mechanism of Action
Nefopam Hydrochloride is a centrally acting analgesic with a rapid onset of action. The main site of action appears to be in the central nervous system both at the brain and spinal levels. In vitro experiments have shown Nefopam to inhibit the re-uptake of various catecholamines (including noradrenaline, serotonin and dopamine). It is possible that the mechanism of action of nefopam is at least in part by altering the levels of these neuromodulators in the brain and at the spinal level.