Moxikem
Generic: Moxifloxacin Hydrochloride
Dose Regimen:
Course Duration:
Alternatives (24)Cheaper & Alternative Brands (0.5%)
Same active generic (Moxifloxacin Hydrochloride), same form (Ophthalmic Solution), exact same strength (0.5%)
Clinical Prescribing Information
Medical monograph and safety information for healthcare professionals & patients.Indications & Clinical Uses
Avaflox tablet is indicated for the treatment of acute bacterial sinusitis, acute exacerbation of chronic bronchitis, community acquired pneumonia, uncomplicated & complicated skin and skin structure infections, complicated intra-abdominal infections and pelvic inflammatory disease.
Dosage & Administration
Acute bacterial sinusitis
: 400 mg once daily 7-10 days.
Acute bacterial exacerbation of chronic bronchitis
: 400 mg once daily 5-10 days.
Community-acquired pneumonia
: 400 mg once daily 7-14 days.
Uncomplicated skin and skin structure infections
: 400 mg once daily 7 days.
Complicated skin and skin structure infections
: 400 mg once daily 7-21 days.
Complicated intra-abdominal infections
: 400 mg once daily 5-14 days.
Pelvic inflammatory disease
: 400 mg once daily 14 days.
Contraindications
It is contraindicated in patients with a history of hypersensitivity to Moxifloxacin or other quinolones.
Side Effects & Adverse Reactions
Common side effects of Avaflox include nausea, vomiting, diarrhea, headache and dizziness.
Warnings & Precautions
Avaflox may cause an increased risk of tendinitis and tendon rupture. It should be discontinued if pain or inflammation in a tendon occurs. It should not be used in patients with known prolongation of the QT interval, patients with uncorrected hypokalemia, and patients with receiving Class IA or Class III antiarrhythmic agents
Pharmacology & Mechanism of Action
Moxifloxacin is a 4th generation synthetic broad spectrum, fluoroquinolone class of antibacterial drug. It has activity against a wide range of gram-positive, gram-negative, anaerobic and atypical bacteria including Mycoplasma pneumoniae. It acts by inhibiting topoisomerase II (DNA gyrase) and topoisomerase IV which are necessary for bacterial DNA replication, transcription & repair.