Herpigel
Generic: Ganciclovir
Dose Regimen:
Course Duration:
Alternatives (6)Cheaper & Alternative Brands (0.15%)
Same active generic (Ganciclovir), same form (Ophthalmic Gel), exact same strength (0.15%)
Clinical Prescribing Information
Medical monograph and safety information for healthcare professionals & patients.Indications & Clinical Uses
Ganrux ophthalmic gel is a topical eye antiviral that is indicated for the treatment of acute herpetic keratitis (dendritic ulcers)
Dosage & Administration
The recommended dosing regimen for Ganciclovir eye gel 0.15% is 1 drop in the affected eye 5 times per day (approximately every 3 hours while awake) until the corneal ulcer heals and then 1 drop 3 times per day for 7 days.
Contraindications
It is contraindicated to the patients with known hypersensitivity to Ganciclovir.
Side Effects & Adverse Reactions
Most common adverse reactions reported in patients were blurred vision (60%), eye irritation (20%), punctate keratitis (5%), and conjunctival hyperemia (5%).
Warnings & Precautions
It is indicated for topical eye use only. Patients should not wear contact lenses if they have signs or symptoms of herpetic keratitis or during the course of therapy with it.
Pharmacology & Mechanism of Action
This eye gel contains the active ingredient, Ganciclovir, which is a guanosine derivative that, upon phosphorylation, inhibits DNA replication by herpes simplex viruses (HSV). Ganciclovir is transformed by viral and cellular thymidine kinases (TK) to ganciclovir triphosphate, which acts as an antiviral agent by inhibiting the synthesis of viral DNA in two ways: competitive inhibition of viral DNA-polymerase and direct incorporation into viral primer strand DNA, resulting in DNA chain termination and prevention of DNA replication.