Giran
Generic: Candesartan Cilexetil
Daily Dose:
Duration:
Cheaper & Alternative Brands (16 mg)
Same active generic (Candesartan Cilexetil), same form (Tablet), exact same strength (16 mg)No other brands are currently registered in Bangladesh for the 16 mg presentation. Below are available brands for Candesartan Cilexetil in other strengths:
Clinical Prescribing Information
Medical monograph and safety information for healthcare professionals & patients.Indications & Clinical Uses
Giran is indicated for hypertension, heart failure with impaired left ventricular systolic function.
Dosage & Administration
Hypertention
: initially 8 mg (hepatic impairment 2 mg, renal impairment or intravascular volume depletion 4 mg) once daily, increased if necessary at intervals of 4 weeks to max 32 mg once daily; usual maintenance dose 8 mg once daily.
Heart failure
: initially 4 mg once daily, increased at intervals of at least 2 weeks to target dose of 32 mg once daily or to max tolerated dose.
Contraindications
Hypersensitivity to any component of this product. Pregnancy, breast-feeding, cholestasis.
Side Effects & Adverse Reactions
Side-effects are usually mild. Symptomatic hypotension including dizziness may occur, particularly in patients with intravascular volume depletion (e.g. those taking high dose diuretics). Hyperkalemia occurs occassionally; angioedema has also been reported with some angiotension II receptor antagonist. Also vertigo, headache; rarely hepatitis, blood disorders, hyponatraemia, back pain, arthralgia, myalgia, rash, urticaria, pruritous.
Warnings & Precautions
Giran should be used with caution in renal artery stenosis, aortic or mitral valve stenosis and in obstructive hypertropic cardiomyopathy. Monitoring of plasma-potassium concentration is advised, particularly in the elderly and in patients with renal impairment; lower initial doses may be appropriate in these patients.
Pharmacology & Mechanism of Action
Candesartan Cilexetil is an ester prodrug that is hydrolysed in the body to the active form Candesartan during absorption from the gastro-intestinal tract. Candesartan is angiotensin II receptor (type AT1) antagonist. Candesartan blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT1 receptor in many tissues (eg, vascular smooth muscle, adrenal gland).