Fliban
Generic: Flibanserin
Daily Dose:
Duration:
Alternatives (5)Cheaper & Alternative Brands (100 mg)
Same active generic (Flibanserin), same form (Tablet), exact same strength (100 mg)
Clinical Prescribing Information
Medical monograph and safety information for healthcare professionals & patients.Indications & Clinical Uses
Desire tablet is indicated for the treatment of premenopausal women with acquired, generalized hypoactive sexual desire disorder (HSDD) as characterized by low sexual desire that causes marked distress or interpersonal difficulty and is not due to:
A co-existing medical or psychiatric condition
Problems within the relationship, or
The effects of a medication or other drug substance
Dosage & Administration
Recommended dosage of Flibanserin
: 100 mg taken once daily at bedtime.
Pediatric Use
: Not recommended in patients below 18 years of age.
Geriatric Use
: Flibanserin is not indicated for use in geriatric patients. Safety and effectiveness have not been established in geriatric patients.
Contraindications
Flibanserin is contraindicated:
With use of alcohol,
With concomitant use with moderate or strong CYP3A4 inhibitors,
In patients with hepatic impairment.
Side Effects & Adverse Reactions
Most common side effects are Dizziness, Somnolence, Nausea, Fatigue, Insomnia, Dry mouth.
Warnings & Precautions
Patients with pre-syncope should immediately lie supine and promptly seek medical help if symptoms do not resolve. Exacerbated by other CNS depressants and in settings where Desire concentrations are increased. Patients should avoid activities requiring full alertness (e.g., operating machinery or driving) until at least 6 hours after each dose and until they know how Desire affects them.
Pharmacology & Mechanism of Action
The mechanism of action of Flibanserin in the treatment of premenopausal women with hypoactive sexual desire disorder is not known. Flibanserin demonstrated high affinity for 5-HTIA & 5-HT2A receptors, showing agonist activity on 5-HTIA & antagonist on 5-HT2A, resulting in lowering of serotonin in the brain as well as effect on increasing norepinephrine and dopamine neurotransmitters.