Eluxan
Generic: Eluxadoline
Daily Dose:
Duration:
Cheaper & Alternative Brands (75 mg)
Same active generic (Eluxadoline), same form (Tablet), exact same strength (75 mg)No other brands are currently registered in Bangladesh for the 75 mg presentation. Below are available brands for Eluxadoline in other strengths:
Clinical Prescribing Information
Medical monograph and safety information for healthcare professionals & patients.Indications & Clinical Uses
Eluxan is indicated in adults for the treatment of irritable bowel syndrome with diarrhea (IBS-D).
Dosage & Administration
The recommended dose is 75 mg tablet taken orally twice daily with food. Patients who develop severe constipation for more than 4 days have to discontinue the drug. If a dose is missed, patient should take the next dose at the regular time and avoid taking two doses at a time.
Pediatric Use
: Safety and effectiveness in pediatric patients have not been established.
Hepatic Impairment
: It is contraindicated in patients with severe hepatic impairment.
Contraindications
Known or suspected biliary duct obstruction, sphincter of oddi disease or dysfunction & pancreatitis.
Side Effects & Adverse Reactions
Most common adverse reactions are constipation, nausea and abdominal pain.
Warnings & Precautions
Sphincter of Oddi spasm and Pancreatitis.
Patients who should be monitored closely-
without a gallbladder
with new or worsening abdominal pain
with nausea and vomiting
with acute biliary pain
with liver or pancreatic enzyme elevation
Pharmacology & Mechanism of Action
Eluxadoline is a mu-opioid receptor agonist, kappa opioid receptor agonist & delta opioid receptor antagonist. Eluxadoline works directly in intestine to reduce peristalsis, also makes the nerves in intestine less sensitive to stimulation.