Diphedan
Generic: Phenytoin Sodium
Daily Dose:
Course Duration:
Cheaper & Alternative Brands (30 mg/5 ml)
Same active generic (Phenytoin Sodium), same form (Oral Suspension), exact same strength (30 mg/5 ml)No other brands currently registered with this exact active generic and dosage form.
Clinical Prescribing Information
Medical monograph and safety information for healthcare professionals & patients.Indications & Clinical Uses
D-Toin is an anticonvulsant which is used in the treatment of status epilepticus of grandmal type. It may also be used in the prevention and treatment of seizures occur during neurosurgery.
Dosage & Administration
Adults
: 200 mg (2 tablets) daily increased to 400 mg (Maximum 600 mg/day) daily in divided doses or 3-4 mg/kg daily in divided doses. For adult patients (who have received no previous medication) the treatment is one tablet three times daily or as directed by the physician.
Children
: Initially, 5 mg/kg per day in two or three equally divided dosage, with subsequent dosage individualized to maximum 300 mg daily. A recommended daily maintenance dosage is usually 4 to 8 mg/kg. Children over 6 years require the minimal adult dose (300 mg/day).
Contraindications
Phenytoin is contraindicated in those patients who are hyper sensitive to phenytoin and hydentoins.
Side Effects & Adverse Reactions
Skin rashes may occasionally develop but they disappear when treatment is discontinued. Therapy may then be resumed with lower doses. Insomnia, slurred speech, transient nervousness, dizziness, headache may also occur.
Warnings & Precautions
In prolonged treatment periodic checking of the blood is advisable. Dose should be discontinued if skin rashes appears. Hyperglycemia resulting from the drug inhibitory effects on insulin release has been reported. It should be used with caution in pregnancy and in nursing mother.
Pharmacology & Mechanism of Action
Phenytoin acts as an anticonvulsant by increasing efflux or decreasing influx of sodium ions across cell membranes in the motor cortex during generation of nerve impulses; thus stabilising neuronal membranes and decreasing seizure activity. It acts as an antiarrhythmic by extending the effective refractory period and suppressing ventricular pacemaker automaticity, shortening action potential in the heart.