Calcitonin
Generic: Salmon Calcitonin
Daily Dose:
Course Duration:
Cheaper & Alternative Brands (100 IU/ml)
Same active generic (Salmon Calcitonin), same form (Injection), exact same strength (100 IU/ml)No other brands currently registered with this exact active generic and dosage form.
Clinical Prescribing Information
Medical monograph and safety information for healthcare professionals & patients.Indications & Clinical Uses
Calcitonin is indicated in Active Paget's disease in patients who do not respond to alternative treatments or for whom such treatments are not suitable; Hypercalcaemia.
Dosage & Administration
Intravenous (Adult)-
Emergency treatment of hypercalcaemia
: Up to 10 u/kg in 500 mL of sodium chloride 0.9% by slow IV infusion over at least 6 hr.
Parenteral (Adult)-
Adjunct in hypercalcaemia:
SC/IM: 4 u/kg 12 hrly, may increase after 1-2 days to 8 u/kg 12 hrly to max 8 u/kg 6 hrly after 2 days. Alternatively, 100 u every 6-8 hr, increased after 1-2 days to max 400 u every 6-8 hr.
Paget's disease of bone:
SC/IM: 50 u 3 times wkly to 100 u/day.
Nasal (Adult)-
Nasal postmenopausal osteoporosis:
200 u/day, alternation nostrils everyday.
Contraindications
Hypersensitivity. Patients with hypocalcaemia.
Side Effects & Adverse Reactions
GI disturbances, dizziness, flushing, tingling of the hands, unpleasant taste, skin rash, abdominal pain, urinary frequency, tremor, inj site inflammation. Rarely, diabetogenic effect.
Warnings & Precautions
Skin test should be done before initiating therapy. Heart failure; renal impairment. Pregnancy, lactation, childn.
Pharmacology & Mechanism of Action
Calcitonin is a polypeptide hormone produced by the ultimobranchial gland in non-mammalian vertebrates or by the mammalian thyroid parafollicular cells. It inhibits osteoclastic bone resorption and reduces bone turnover. It decreases tubular reabsorption and promotes renal excretion of Ca, Cl, Na, Mg, K and phosphate.