Atofix
Generic: Difamilast
Application:
Course Duration:
Cheaper & Alternative Brands (0.3% w/w)
Same active generic (Difamilast), same form (Ointment), exact same strength (0.3% w/w)No other brands are currently registered in Bangladesh for the 0.3% w/w presentation. Below are available brands for Difamilast in other strengths:
Clinical Prescribing Information
Medical monograph and safety information for healthcare professionals & patients.Indications & Clinical Uses
Atofix ointment is used topically to treat atopic dermatitis, commonly known as eczema.
Dosage & Administration
The usual adult dosage is an appropriate amount of the Difamilast 1% ointment applied to the affected area twice daily. The usual pediatric dosage is an appropriate amount of the Difamilast 0.3% ointment applied to the affected area twice daily.
Contraindications
Difamilast is contraindicated in individuals with a known hypersensitivity to the drug.
Side Effects & Adverse Reactions
Well tolerated in recommended dosage. At higher dosage it may cause mild skin reactions at the site of application, such as redness, burning, or stinging.
Warnings & Precautions
External use only. Atofix ointment is not for oral, ophthalmic, or intravaginal use.
If there is any hypersensitivity issue with the use of Atofix, treatment should be discontinued.
Pharmacology & Mechanism of Action
Difamilast is a phosphodiesterase 4 (PDE4) inhibitor. It increases cyclic adenosine 3',5'-monophosphate (cAMP) concentration and consequently suppresses the production of inflammatory cytokines, exerting effects in treatment of atopic dermatitis.