Anacaine HC
Generic: Hydrocortisone + Lidocaine
Application:
Course Duration:
Cheaper & Alternative Brands (0.5% + 3%)
Same active generic (Hydrocortisone + Lidocaine), same form (Cream), exact same strength (0.5% + 3%)No other brands currently registered with this exact active generic and dosage form.
Clinical Prescribing Information
Medical monograph and safety information for healthcare professionals & patients.Indications & Clinical Uses
Anacaine HC ano-rectal cream is used for the anti-inflammatory and anesthetic relief form itching, pain, soreness and discomfort due to hemorrhoids, anal fissures, anal pruritus and similar conditions of the anal area.
Dosage & Administration
This cream should be applied to the affected area(s) twice daily or as directed by physician. Applicator tip should be gently inserted into the anal area (areas of discomfort and anal opening). Applicator and tube should not completely insert in the anus or rectum.
Pediatric Use: Safety and efficacy in pediatric patients have not been established.
Contraindications
Patients with a history of hypersensitivity to any of its ingredients.
Side Effects & Adverse Reactions
During or immediately following application of Anacaine Cream, there may be transient stinging or burning from open areas of skin, or transient blanching (lightening), or erythema (redness) of the skin.
Warnings & Precautions
If infection occurs, the drug should be discontinued. Systemic absorption may occur when extensive areas are treated and may cause suppression of hypothalamic-pituitary-adrenal (HPA) axis; avoid using for prolonged periods or with occlusive dressings. Caution should be used with impaired hepatic function and patients taking class I antiarrhythmics.
Pharmacology & Mechanism of Action
Hydrocortisone
is a corticosteroid used for its anti-inflammatory and immunosuppressive effects. Its anti-inflammatory action is due to the suppression of migration of polymorphonuclear leukocytes and reversal of increased capillary permeability. It may also be used as replacement therapy in adrenocortical insufficiency.
Lidocaine
is an amide type local anesthesia. It stabilises the neuronal membrane and inhibits Na ion movements, which are necessary for conduction of impulses. In the heart, lidocaine reduces depolarisation of the ventricles during diastole and automaticity in the His-Purkinje system. Duration of action potential and effective refractory period are also reduced.