Ampimet DS
Generic: Ampicillin Sodium
Daily Dose:
Course Duration:
Alternatives (2)Cheaper & Alternative Brands (125 mg/5 ml)
Same active generic (Ampicillin Sodium), same form (Oral Suspension), exact same strength (125 mg/5 ml)
Clinical Prescribing Information
Medical monograph and safety information for healthcare professionals & patients.Indications & Clinical Uses
Acmecilin is indicated in the treatment of infections caused by susceptible strains of the designated organism listed below:
Infections of the Genitourinary Tract Including Gonorrhea
: E. coli, P. mirabilis, enterococci, Shigella, S. typhosa and other Salmonella, and nonpenicillinase-producing N. gononhoeae.
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Acmecilin is indicated in the treatment of infections caused by susceptible strains of the designated organism listed below:
Infections of the Genitourinary Tract Including Gonorrhea
: E. coli, P. mirabilis, enterococci, Shigella, S. typhosa and other Salmonella, and nonpenicillinase-producing N. gononhoeae.
Infections of the Respiratory Tract
: Nonpenicillinase-producing H. influenzae and staphylococci, and streptococci including streptococcus pneumoniae.
Infections of the Gastrointestinal Tract
: Shigella, S. typhosa and other Salmonella, E. coli, P. mirabilis, and enterococci.
Meningitis
: O. Meningitides.
Bacteriology studies to determine the causative organisms and their sensetivity to ampicillin should be performed. Therapy may be instituted prior to the results of susceptibility testing.
Contraindications
Hypersensitivity to ampicillin and other penicillins.
Side Effects & Adverse Reactions
Nausea, vomiting, diarrhoea, erythematous maculo-papular rashes, sore mouth, black/hairy tongue, rash, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis, angioedema, fever, joint pains, serum sickness-like symptoms, haemolytic anaemia, thrombocytopenia, leucopenia, neutropenia, coagulation disorders, prolonged bleeding time and prothrombin time, CNS toxicity (e.g. convulsions); paraesthesia, nephropathy, interstitial nephritis, hepatitis, cholestatic jaundice, moderate and transient increase in transaminases, Anaphylaxis, Clostridium difficile-associated diarrhoea (CDAD).
Warnings & Precautions
Patient with history of β-lactam allergy. During renal impairment, Pregnancy and lactation.
Pharmacology & Mechanism of Action
Ampicillin inhibits bacterial cell wall synthesis by binding to 1 or more of the penicillin-binding proteins (PBPs) which in turn inhibit the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls. Bacteria eventually lyse due to ongoing activity of cell wall autolytic enzymes (autolysins and murein hydrolases) while cell wall assembly is arrested.