BD MediTamsulosin Hydrochloride
BPH/ Urinary retention/ Urinary incontinence
Brands & Prices (42)
📋 Indications & Uses Dosage & Administration⚠️ Contraindications⚡ Side Effects & Adverse Reactions🛡️ Warnings & Precautions🔬 Pharmacology & Mechanism
Brand Formulations & Prices
42 brands sorted by unit price
Flosure
Tamurin
Prostanil MR
Tamsulin
Urivent
Uropro
Eziflo
Ezipas
Hi-Flow
Inturia
Maxipass
Maxtra
Mictrol
Prostacin
Prostaglen
Prosulin
Tamisol MR
Tamlet
Tamosin
Tamsin
Tamsol
Taspia
Uricare SR
Urinom
Urinom MR
Urocap
Urocare
Uroflo
Urosin
Urotam
Flonor
Maxflo-U
Tamfast
Tamsule SR
Prostam
Sasolin MR
Tamlosin
Urolosin
Uropass
Tamcontin
Maxrin
Uromax
📖 Official Clinical Monograph
DGDA Approved Prescribing GuidelinesEziflo is indicated for the treatment of functional symptoms of Benign Prostatic Hyperplasia (BPH).
Dosage & AdministrationTamsulosin Hydrochloride 0.4 mg (one capsule) daily, to be taken after meal at night. The dose may be increased after 2 to 4 weeks, if necessary, to Tamsulosin Hydrochloride 0.8 mg (two capsules) once daily. If Tamsulosin Hydrochloride administration is discontinued or interrupted for several days at either the 0.4 mg or 0.8 mg dose, therapy should be started again with the Tamsulosin Hydrochloride 0.4 mg (one capsule) once daily dose. The capsule should be swallowed whole with a glass of water (about 150 ml) in the standing or sitting position. The capsule should not be crunched or chewed, as this will interfere with the modified release of the active ingredient.
Tamsulosin hydrochloride is contraindicated in patients with hypersensitivity to it; history of orthostatic hypotension; severe hepatic insufficiency.
As with other alpha1 blockers, a reduction in blood pressure can occur in individual cases during treatment with Tamsulosin, as a result of which, rarely, syncope can occur, at the first signs of orthostatic hypotension (dizziness, weakness) the patient should sit or lie down until the symptoms have disappeared. And they should be cautioned to avoid situations where injury could result (like driving, operating machinery or performing hazardous tasks).
Before therapy with Tamsulosin is initiated the patient should be examined in order to exclude the presence of other conditions which can cause the same symptoms as Benign Prostatic hyperplasia. Digital rectal examination and when the necessary determination of Prostate Specific Antigen (PSA) should be performed before treatment and at regular intervals afterwards.
The following adverse reactions have been reported during the use of Eziflo: dizziness, abnormal ejaculation and; less frequently headache, asthenia, postural hypotension and palpitations.
Rarely, transient postural symptoms have occurred during orthostatic provocation testing after the first dose. Use in patients with micturition syncope is not advised.
Effects on ability to drive and use machines: No data is available on whether Eziflo adversely affects the ability to drive or operate machines. However, in this respect, patients should be aware of the fact that dizziness can occur.
Tamsulosin, a selective alpha1 adrenoceptor blocking agent, exhibits its selectivity for alpha1 A adrenoceptors in human prostate. Blockade of these adrenoceptors can cause smooth muscle in the bladder neck and prostate to relax, resulting in an improvement in urine flow rate and a reduction in symptoms of BPH. Absorption of Tamsulosin hydrochloride capsule 0.4mg is essentially complete (90%) following oral administration under fasting conditions. The time to maximum concentration (Tmax) is reached by four to five hours under fasting conditions and by six to seven hours when administered with food. Tamsulosin hydrochloride is extremely bound to human plasma protein (94% to 99%). Tamsulosin hydrochloride is extensively metabolized by cytochrome P 450 enzymes in the liver and less than 10% of the dose is excreted in urine as unchanged form. Following intravenous or oral administration of an immediate-release formulation the elimination half-life of Tamsulosin hydrochloride in plasma ranges from five to seven hours. Because of the absorption rate controlled pharmacokinetics with Prostam capsules, the apparent half-life of Tamsulosin hydrochloride is approximately 9 to 13 hours in healthy volunteers and 14 to 15 hours in the target population.