BD MediSalmeterol Xinafoate
Long-acting selective β-adrenoceptor stimulants
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📋 Indications & Uses⚠️ Contraindications⚡ Side Effects & Adverse Reactions🛡️ Warnings & Precautions🔬 Pharmacology & Mechanism
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📖 Official Clinical Monograph
DGDA Approved Prescribing GuidelinesSeravent is indicated for reversible airways obstruction (including nocturnal asthma and prevention of exercise-included bronchospasm) in patients requiring long term regular bronchodilator therapy.
lt is contraindicated in patients with khown to have hypersensitivity to the drug.
Adverse effects which have been associated with Seravent are dose related tremor, subjective palpitations and headaches are usually mild and transient, muscle pain, stiffness, chest pain, rash have also been reported.
Inhalation of Seravent may be associated with paradoxical bronchospasm and it should not be used in patients who are not also receiving and inhaled corticosteroid. Seravent is not appropriate for the treatment of acute symptoms.
Beta-2 adrenoceptor stimulation causes relaxation of bronchial smooth muscle, bronchodilation, and increased airflow. Salmeterol is hypothesized to bind to 2 sites on the beta-2 adrenoceptor.1 The saligenin moiety binds to the active site of the beta-2 adrenoceptor. The hydrophilic tail of salmeterol binds to leucine residues in the exo-site of the beta-2 adrenoceptor almost irreversibly, allowing salmeterol to persist in the active site, which is responsible for it's long duration of action. Another hypothesis is that the lipophilic drug diffuses into lipid bilayer of smooth muscle cells and provides a depot of drug to the cells over a longer period of time.