Moxifloxacin Hydrochloride + Xanthan Gum

This ophthalmic solution is indicated for the treatment of bacterial conjunctivitis caused by susceptible strains of the following organisms-
Aerobic Gram-positive microorganisms
: Corynebacterium Species, Micrococcus Luteus, Staphylococcus Aureus, Staphylococcus Epidermidis
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This ophthalmic solution is indicated for the treatment of bacterial conjunctivitis caused by susceptible strains of the following organisms-
Aerobic Gram-positive microorganisms
: Corynebacterium Species, Micrococcus Luteus, Staphylococcus Aureus, Staphylococcus Epidermidis, Staphylococcus Haemolyticus, Staphylococcus Hominis, Staphylococcus Warneri, Streptococcus Pneumonia, Streptococcus Viridans group.
Aerobic Gram-negative microorganisms
: Acinetobacter Iwoffii, Haemophilus Influenza, Haemophilus Parainfluenzae.

Dosage & Administration

One drop in the affected eye(s) 2 times daily for 7 days.
Pediatric Use
: The safety and effectiveness of Moxifloxacin in infants below four months of age was not proven. However, several clinical studies show that the drug may be used safely in children even younger than one month of age.
Geriatric Use
: No overall differences in safety and effectiveness have been observed between elderly and younger patients.

In 1-6% patients the most frequently reported ocular adverse events are eye irritation, pyrexia, conjunctivitis, decreased visual acuity, dry eye, ocular discomfort, ocular hyperemia, ocular pain, ocular pruritus, subconjunctival hemorrhage and tearing.

The antimicrobial action of Moxifloxacin results from inhibition of the topoisomerase II (DNA gyrase) and topoisomerase IV. DNA gyrase is an essential enzyme that is involved in the replication, transcription and repair of bacterial DNA. Topoisomerase IV is an enzyme known to play a key role in the partitioning of the chromosomal DNA during bacterial cell division.