BD MediFosfomycin Sodium
Intracellular antibiotic
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📋 Indications & Uses⚠️ Contraindications⚡ Side Effects & Adverse Reactions🛡️ Warnings & Precautions🔬 Pharmacology & Mechanism
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📖 Official Clinical Monograph
DGDA Approved Prescribing GuidelinesFosfomax IV Infusion is indicated for the treatment of the following infections in adults and children including neonates:
Osteomyelitis
Complicated urinary tract infections
Nosocomial lower respiratory tract infections
Bacterial meningitis
Bacteraemia that occurs in association with, or is suspected to be associated with, any of the infections listed above
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Fosfomax IV Infusion is indicated for the treatment of the following infections in adults and children including neonates:
Osteomyelitis
Complicated urinary tract infections
Nosocomial lower respiratory tract infections
Bacterial meningitis
Bacteraemia that occurs in association with, or is suspected to be associated with, any of the infections listed above
Fosfomax should be used only when it is considered inappropriate to use antibacterial agents that are commonly recommended for the initial treatment of the infections listed above, or when these alternative antibacterial agents have failed to demonstrate efficacy.
Hypersensitivity to the active substance, fosfomycin, or to any of the excipients.
The most commonly reported adverse reactions during treatment are gastrointestinal disturbances and injection site reactions. Other important adverse reactions include hypokalaemia and/or hypernatraemia.
To avoid potential development of cross resistance co-administration of Fosfomax with other antibiotics is preferred.
A high sodium load associated with the use of fosfomycin may result in decreased levels of potassium in serum or plasma. A low-sodium diet is recommended during treatment. The substitution of potassium may be necessary in some cases. Serum electrolyte levels and water balance must be monitored during therapy. Caution is advised when fosfomycin is used in patients with cardiac insufficiency, hypertension, hyperaldosteronism, hypernatraemia or pulmonary edema.
Acute, potentially life-threatening hypersensitivity reactions (anaphylactic shock) may occur in very rare cases. At the first signs (including sweating, nausea, cyanosis), the infusion of fosfomycin must be immediately discontinued.
Fosfomycin exerts a bactericidal effect on proliferating pathogens by preventing the enzymatic synthesis of the bacterial cell wall. Fosfomycin inhibits the first stage of intracellular bacterial cell wall synthesis by blocking peptidoglycan synthesis.