Flucloxacillin Sodium

207 Registered Brands From ৳4.60 / unit

Narrow spectrum penicillin

Brands & Prices (207) 📋 Indications & Uses ⚠️ Contraindications ⚡ Side Effects & Adverse Reactions 🛡️ Warnings & Precautions 🔬 Pharmacology & Mechanism

Brand Formulations & Prices

207 brands sorted by unit price

📖 Official Clinical Monograph

DGDA Approved Prescribing Guidelines

📋 Indications & Uses

A-Flox is indicated for the treatment of infections due to Gram-positive organisms, including infections caused by penicillinase producing staphylococci. These indications include:
Skin and soft tissue infections: Boils, abscess, carbuncles, infected skin conditions (e.g. ulcer, eczema, acne, furunculosis, cellulitis, infected wounds, infected burns, otitis media and externa, impetigo).
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A-Flox is indicated for the treatment of infections due to Gram-positive organisms, including infections caused by penicillinase producing staphylococci. These indications include:
Skin and soft tissue infections: Boils, abscess, carbuncles, infected skin conditions (e.g. ulcer, eczema, acne, furunculosis, cellulitis, infected wounds, infected burns, otitis media and externa, impetigo).
Respiratory tract infections: Pneumonia, lung abscess, empyema, sinusitis, pharyngitis, tonsillitis, quinsy.
It is also used for the treatment of other infections i.e. osteomyelitis, enteritis, endocarditis, urinary tract infection, meningitis, septicaemia caused by A-Flox-sensitive organisms.
As a prophylactic agent, it is used during major surgical procedures where appropriate; for example, cardiothoracic and orthopedic surgery.

⚠️ Contraindications

Flucloxacillin is contraindicated in penicillin hypersensitive patients.

⚡ Side Effects & Adverse Reactions

There have been some common side effects of gastrointestinal tract such as nausea, vomiting, diarrhoea, dyspepsia and other minor gastrointestinal disturbances. Besides these rashes, urticaria, purpura, fever, interstitial nephritis, hepatitis and cholestatic jaundice have been reported.

🛡️ Warnings & Precautions

A-Flox should be used with caution in patients with evidence of hepatic dysfunction. Caution should also be exercised in the treatment of patients with an allergic diathesis.

🔬 Pharmacology & Mechanism

Flucloxacillin is active against Gram-positive organisms including penicillinase producing strains. It has little activity against Gram-negative bacilli. Flucloxacillin acts by inhibiting the formation of cell wall of bacteria. Flucloxacillin is isoxazolyl penicillin which combined the properties of resistance to hydrolysis by penicillinase, gastric acid stability and activity against gram-positive bacteria. Flucloxacillin is a bactericidal antibiotic that is particularly useful against penicillinase-producing staphylococci. Flucloxacillin kills bacterial cellwall, thus interfering with peptidoglycan synthesis. Peptidoglycan is a heteropolymeric structure that provides the cell wall with its mechanical stability. The final stage of peptidoglycan synthesis involves the completion of the cross-linking with the terminal glycine residue of the pentaglycin bridge linking to the fourth residue of the pentapeptide (D-alanine). The transpeptidase enzyme that performs this step is inhibited by Flucloxacillin. As a result the bacterial cellwall is weakened, the cell swells and then ruptures. Flucloxacillin resists the action of bacterial penicillinase probably because of the steric hindrance induced by the acyl side chain which prevents the opening of the β- lactam ring.

Flucloxacillin Sodium

Brand Formulations & Prices

Fluxicap

Clox-F

Flac

Floxason

Flxzen

Uflu

Sofa

Ancoc

Faxilin

Flubex

Flucillin

Flucloxi

Fluking

Flunid

Flupen

Flustaph

Flustar

Inclox

Isoclox

Monaclox-F

Stafoxin

Stapkil

Flucopen

Flox

Flubiotic

Halopen

Orgaflu

Fluxin

Sinaflox

Cloxafu

Flutam

Flutec

Flucloxin

Flux

Silox

Eflucin

Staflu

Floxabac

Floxapen

Flukin

Revistar

Skilox

Doribac

Flutam

Luf

Flu-K

Flox R

G-Flucloxacillin

S-Fluclox

A-Flox

Flubac

Flucin

Fluclox

Flxzen

Phylopen

Ancoc

Bdflox

Belox

Clox-F

Debac

Dolopen

Faxilin

Flac

Floxason-DS

Fluc

Flucil