Econazole Nitrate

Ecoderm is indicated for topical application-
In the treatment of tinea pedis, tinea cruris, and tinea corporis caused by Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton tonsurans, Microsporum canis, Microsporum audouini, Microsporum gypseum, and Epidermophyton floccosum,
In the treatment of cutaneous candidiasis, and in the treatment of tinea versicolor.

Dosage & Administration

Econazole vaginal tablet
: One tablet should be inserted deep into the vagina at bed time for three consecutive nights. Treatment should be continued even if menstruation occurs. Although a three night course of treatment is often sufficient longer courses are advisable for women with recurrent vaginal infections.
Econazole 30 gm cream
: The supplied applicator should be filled with econazole cream and then inserted deep into the vagina at bedtime once or twice daily.
Econazole 10 gm cream
: Apply sparingly to the affected area once or twice daily until improvement occurs.
Sufficient Econazole cream should be applied to cover affected areas once daily in patients with tinea pedis, tinea cruris, tinea corporis, and tinea versicolor, and twice daily (morning and evening) in patients with cutaneous candidiasis. Early relief of symptoms is experienced by the majority of patients and clinical improvement may be seen fairly soon after treatment is begun; however, candidal infections and tinea cruris and corporis should be treated for two weeks and tinea pedis for one month in order to reduce the possibility of recurrence. If a patient shows no clinical improvement after the treatment period, the diagnosis should be redetermined. Patients with tinea versicolor usually exhibit clinical and mycological clearing after two weeks of treatment.

During clinical trials, approximately 3% of patients treated with Ecoderm 1% cream reported side
effects thought possibly to be due to the drug, consisting mainly of burning, itching, stinging, and erythema. One case of a pruritic rash has also been reported.

Econazole Nitrate interferes with fungal oxidative enzymes to cause lethal accumulation of H
2
O
2
. They also reduce the formation of ergosterol, an important constituent of fungal cell wall.