BD MediColistimethate Sodium
Other antibacterial preparation
Brands & Prices (12)
📋 Indications & Uses⚠️ Contraindications⚡ Side Effects & Adverse Reactions🛡️ Warnings & Precautions🔬 Pharmacology & Mechanism
Brand Formulations & Prices
12 brands sorted by unit price
Gigabac
Megabac
Yonex
Colistimethate Sodium Altan
Megabac
Yonex
Gigabac
Megabac
Xylistin
Yonex
Colistimethate (CMS)
Colistimethate (CMS)
📖 Official Clinical Monograph
DGDA Approved Prescribing GuidelinesColistimethate (CMS) is indicated for the treatment of acute or chronic infections caused by sensitive strains of certain gram-negative bacilli. It is particularly indicated in the infection caused by sensitive strains of Pseudomonas aeruginosa. Colistimethate (CMS) is not indicated for infections due to Proteus
... Read more
Colistimethate (CMS) is indicated for the treatment of acute or chronic infections caused by sensitive strains of certain gram-negative bacilli. It is particularly indicated in the infection caused by sensitive strains of Pseudomonas aeruginosa. Colistimethate (CMS) is not indicated for infections due to Proteus or Neisseria. Colistimethate (CMS) is very effective in the treatment of infections due to the following gram-negative organisms: Enterobacter aerogenes, Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa.
The use of Colistimethate Sodium Parenteral is contraindicated for patients with a history of sensitivity to the drug or any of its components.
The following adverse reactions have been reported: gastrointestinal upset, tingling of extremities and tongue, slurred speech, dizziness, vertigo and paresthesia, generalized itching, urticaria and rash, fever, increased blood urea nitrogen (BUN), elevated creatinine and decreased creatinine clearance, respiratory distress and apnea, nephrotoxicity and decreased urine output.
Colistimethate (CMS) should be used with caution in patient with impaired renal function. When actual renal impairment is present, Colistimethate (CMS) may be used, but the greatest caution should be exercised and the dosage should be reduced in proportion to the extent of the impairment. Colistimethate (CMS) should be used with caution in neonates, infants and children.
Colistimethate is a surface active agent which penetrates into and disrupts the bacterial cell membrane. Colistimethate is polycationic and has both hydrophobic and lipophilic moieties. It interacts with the bacterial cytoplasmic membrane, changing its permeability. This effect is bactericidal. There is also evidence that polymyxins enter the cell and precipitate cytoplasmic components, primarily ribosomes.