BD MediChloramphenicol + Lidocaine Hydrochloride
Anti-infectives & antiseptics, Aural Anti-bacterial preparations
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📋 Indications & Uses Dosage & Administration⚠️ Contraindications⚡ Side Effects & Adverse Reactions🛡️ Warnings & Precautions🔬 Pharmacology & Mechanism
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📖 Official Clinical Monograph
DGDA Approved Prescribing GuidelinesAcute bacterial ear infections
Dosage & AdministrationOtic/Aural Otitis externa
: Instill 2-3 drops into the ear bid-tid.
History of hypersensitivity or toxic reaction to the drug; Perforated ear drum. Herpes simplex and other virul conditions of the eye or ear, mycosis.
Ototoxicity.
Avoid prolonged use. Discontinue immediately if local hypersensitivity reactions occur.
Chloramphenicol
inhibits bacterial protein synthesis by binding to 50s subunit of the bacterial ribosome, thus preventing peptide bond formation by peptidyl transferase. It has both bacteriostatic and bactericidal action against H. influenzae, N. meningitidis and S. pneumoniae.
Lidocaine
is an amide type local anaesth. It stabilises the neuronal membrane and inhibits Na ion movements, which are necessary for conduction of impulses. In the heart, lidocaine reduces depolarisation of the ventricles during diastole and automaticity in the His-Purkinje system. Duration of action potential and effective refractory period are also reduced.